Ibrutix 140mg Capsule

✔️ Uses of Ibrutix 140mg Capsule

• Chronic Lymphocytic Leukemia
• Mantle Cell Lymphoma
• Waldenstrom's Macroglobulinemia
• Marginal Zone Lymphoma
• Chronic graft-versus-host disease (cGVHD)

✔️ How does

This medicine works by inhibiting the actions of certain abnormal proteins that cause the cancer cells to multiply. This helps in stopping the growth and spread of cancer.

✔️ Side Effects of Ibrutix 140mg Capsule

Common side effects include 

• Mouth sores
• Diarrhea
• Skin Rash
• Difficulty in breathing
• Back pain or Joint pain
• Unusual tiredness or weakness
• Muscle pain
• Dizziness
• High blood pressure
• Broken and brittle nails
• Headache
• Pale skin

✔️ Quick Suggestions:

• Take Ibrutix 140mg Capsule at the same time every day, either with or without food.
• It is advisable to stay hydrated and drink plenty of fluids while taking this medication.
• Do not skip any dose and complete the course as suggested by your doctor.
• Use an effective method of birth control to avoid pregnancy while taking this medication.
• Your doctor may get regular blood tests done to monitor your liver function and blood cell count in your blood.

✔️ Indication

Ibrutinib is used to treat certain blood cell and lymph node cancers, as well as chronic graft vs. host disease post-bone marrow transplant.

✔️ Pharmacology

Inhibits BTK enzymatic activity, blocking B-cell antigen receptor and cytokine receptor pathways.

✔️ Dosage & Administration of Ibrutix 140mg Capsule

• Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Waldenström Macroglobulinemia: 420 mg once daily
• Mantle Cell Lymphoma: 560 mg once daily
• Hepatic impairment: Adjust dose

✔️ Interaction

Individual drug interactions can vary, so it's essential to consult your doctor before starting any medication. Here are some points to consider:

• Interaction with Alcohol: The interaction with alcohol is unknown. Consult your doctor before consuming alcohol.
• Interaction with Medicine: Ibrutinib may interact with various medications, including isoniazid, verapamil, sitagliptin, erythromycin, miconazole, azathioprine, clopidogrel, aspirin, ketoconazole, and more. Discuss potential interactions with your doctor.
• Disease Interactions:
  • Atrial Fibrillation: Caution is advised if you have atrial fibrillation or cardiac diseases, as there might be an increased risk of worsening your condition.
  • Liver Impairment: Use caution in patients with mild to moderate liver impairment, and close monitoring of liver function is recommended.
  • Lung Toxicity: If you have a history of interstitial lung disease, watch for new or progressive pulmonary symptoms. Monitoring lung function is essential.
  • Kidney Impairment: Be cautious if you have mild to moderate kidney impairment, with close monitoring of kidney function.
  • Tumor Lysis Syndrome: Be aware of the increased risk of tumor lysis syndrome, especially if you have electrolyte abnormalities and kidney diseases.
• Food Interactions: Avoid grapefruit, grapefruit juice, and Seville oranges as they might cause adverse effects like irregular heart rhythm, diarrhea, nausea, and more.
• Lab Interactions: Specific lab interactions are not provided.

Remember, this isn't a complete list of interactions, and it's crucial to consult your doctor about the medications you're taking to ensure safety and effectiveness.

✔️ Contraindications

• Hypersensitivity
• Concomitant use with St. John's wort-containing preparations

✔️ Pregnancy & Lactation

✔️ Precautions & Warnings

• Monitor bleeding, infections, blood counts, atrial fibrillation, and other malignancies.
• Watch for tumor lysis syndrome.
• Caution in patients with heart, liver, and kidney disorders, seizures, visual issues, and concurrent use with certain medications.

✔️ Storage Conditions

Store at 20-25°C in a dry place. Protect from light.